We are the pioneers of neutrophil transfusion therapies.
Leveraging the full potential of neutrophils
as a therapeutic platform
Neutrophils
... are a major component of the innate immune system and are the most potent antimicrobial cells. They act as the first line of defense and are essential to fight off infections.
Lacking neutrophils can lead to drastically increased susceptibility to severe bacterial and fungal infections. This condition is called neutropenia and is characterized by an abnormally low number of neutrophils in the bloodstream. It is often a side effect of cytostatic drugs used for cancer chemotherapy but can also result from various other causes, such as infections, bone marrow disorders and autoimmune diseases.
Statistics for US, EU5 and Japan:
~3M
Yearly patients receiving at least one chemotherapy course
>120,000
Febrile neutropenia patients experiencing life-threatening complications during chemotherapy
>16,000
Yearly death toll during chemotherapy likely caused by febrile neutropenia
Our near-term vision
Restoring patients' antimicrobial capacity through our CryoEndure neutrophils
CryoEndure neutrophils
Ex vivo-produced neutrophils as basis of an allogeneic cell therapy to clear refractory infections and decrease mortality and ICU time when neither G-CSF nor antibiotics have therapeutic success.
Enabled by
Optimal quantity and efficiency to combat infections
On demand availability through cryopreservation and on-site reconstitution
Insignificant graft vs host reaction expected due to short life-span of transfused cells
Our long-term vision
Deploying genetically enhanced neutrophils to treat pressing medical conditions beyond neutropenia
Antimicrobial resistance
Offering immune
support for hard-to-conquer infections by increased killing capacity
Cancer
Directly targeting tumour indications by armouring of neutrophils with cancer-directed receptors
Autoimmune diseases
Specialized neutrophils to eliminate autoreactive cells to support autoimmune patients
Contact
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Career
If you are interested in a career at NeutroGen Therapeutics, please fill out the contact form or contact us at contact@neutrogen-therapeutics.com.